Projets en cours
Analyses biologiques
- Vesicles in the transmission of ALS (ViTAL) – PIs: Pradat/ Duguez (Paris)
- Insulin Signaling and motor function in ALS (ISMALS) – PIs: Bruneteau/ Lacomblez/ Charbonnier (Paris)
- Do parameters of ferroptotic programmed cell death can predict the progression of the ALS – PIs: Devos/ Rolland/Garçon (Lille)
- Combination of serum and CSF neurofilament light and neuroinflammatory biomarkers to evaluate ALS – PIs: Verschueren/ Boucraut (Marseille)
- ALS-ISO-Marker – PIs: Vigor/ Durand/Devos/Rolland/ Garçon (Montpellier, Lille)
- Measure of the amount of soluble TNFα receptor (sTNFR) in the CSF of ALS patients as biomarker of the dysfunction of PrPC/PDK1/ADAM10-17 signaling pathway in motor neurons – PIs: Shneider, Launay, Baudry, Devos, Rolland (Paris, Lille)
- Detection of HERV-K ENV, TDP-43, NfL and GFAP protein and enterovirus serology in patients with sALS – PIs: Perron, Medina, Charvet GeNeuro (Lyon)
Analyses génétiques
- Gene hunting in Amytrophic lateral sclerosis – PIs: Salachas/ Millecamps (Paris)
- Biomarkers in healthy carriers from familial ALS – PI: Camu (Montpellier)
- Occurrence of TTRE mutation in a prospective cohort of suspected ALS patients – PI: Soriani (Nice)
- SNP-ALS – PIs: Dupuis/ Huin/ Blum/ Rolland/ Devos (Strasbourg/ Lille)
- Unravelling the genetic contribution to prognosis and endophenotypes in ALS using an extended cohort of patients (PULSE WGS) – PI: Dupuis (Strasbourg) Imaging topic (4)
- Machine learning for ALS patient stratification and prognosis prediction: a proof of concept study – PI: Pradat (Paris)
- Radiological factors predicting the evolution of ALS – PIs: Devos/ Lopes/ Viard/ Kuchcinski (Lille)
- Magnetic resonance imaging texture as a biomarker to predict the evolution of ALS – PIs: Devos/ Betrouni (Lille)
Neuropsychologie
- Validation of the French version of the ECAS – PIs: Lacomblez/ Glachant (Paris)
- Impact of habitual caffeine consumption on cognitive impairments in ALS patients – PIs: Blum/ Rolland/ Devos (Lille)
Projets finalisés
Cervical spinal cord MRI as possible biomarker in ALS/ PI: Pradat (Paris) : Article publié dans “Journal of Neurology, Neurosurgery and Psychiatry” en Février 2023: Spinal magnetic resonance imaging better predicting motor functional deterioration in Amyotrophic Lateral Sclerosis than classical clinical factors / (lien vers article de vulgarisation – actus recherche)
Article publié́ dans “Journal of Neurology” en Mars 2024 : Quantitative brainstem and spinal MRI in ALS: implications for predicting non-invasive ventilation needs. (lien vers article de vulgarisation – actus recherche)
Motor unit number index (MUNIX): an electrophysiologic technique to monitor disease progression in ALS/ PIs: Attarian/ Grapperon (Marseille) : Article publié dans “Clinical Neurophysiology“ en Octobre 2021 : Assessment of the upper motor neuron in ALS using triple stimulation technique: a multicenter prospective study / (lien vers article de vulgarisation – actus recherche)